June 5, 1981 - The U.S. Centers for Disease Control and Prevention (CDC) issues its first warning about a rare lung infection, Pneumocystis carinii pneumonia (PCP) circulating in five young, previously healthy, gay men.

1982 - Acquired Immune Deficiency Syndrome (AIDS) is established as the term used to refer to the illness but the cause is still unknown.

The City and County of San Francisco, working with several AIDS service organizations, develop the “San Francisco Model of Care.”

1983 - The World Health Organization (WHO) holds its first meeting to assess the global AIDS situation, and begins international surveillance.

1984 - Community-based AIDS service organizations join together to form AIDS Action, a national organization to advocate on behalf of people and communities affected by the epidemic, to educate, and to help shape AIDS-related policy.

1985 - The U.S. Food and Drug Administration (FDA) licenses the first commercial blood test to detect antibodies to HIV in the blood. Blood banks begin screening the U.S. blood supply.

Ryan White, an Indiana teenager who contracted AIDS through contaminated blood products used to treat his hemophilia, is refused entry to his middle school. He goes on to speak publicly against AIDS stigma and discrimination.

1986 - The virus that causes AIDS is officially named Human Immunodeficiency Virus (HIV).

1986 - Ronald Reagan mentions AIDS publicly for the first time, vowing to Congress to make AIDS a priority.

1987 - The FDA approves the first antiretroviral drug, zidovudine (AZT).

First display of the AIDS Memorial Quilt in Washington covers an acre of the National Mall.

1988 - The WHO declares December 1st to be the first World AIDS Day.

San Francisco establishes the largest needle-exchange program (NEP) in the nation.

1989 - The number of reported AIDS cases in the United States reaches 100,000.

1990 - The U.S. Congress enacts the Americans with Disabilities ACT (ADA), prohibiting the discrimination against individuals with disabilities, including people living with HIV/AIDS.

The U.S. Congress enacts the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act which provides $220.5 million in Federal funds for HIV community-based care and treatment services in its first year.

1991 - AIDS Memorial Grove founded in Golden Gate Park

1991 - The red ribbon becomes the international symbol of AIDS awareness.

1992 - AIDS becomes the number one cause of death for U.S. men ages 25 to 44.

1993 - The FDA approves the female condom.

1994 - AIDS becomes the leading cause of death for all Americans ages 25 to 44.

1995 - The FDA approves the first protease inhibitor which leads to a new era of highly active antiretroviral therapy (HAART).

By the end of the year, 500,000 cases of AIDS have been reported in the U.S.

1996 - The number of new AIDS cases diagnosed in the U.S. declines for the first time since the beginning of the epidemic.

1996 - Congress and President Clinton designate the AIDS Memorial Grove a National Memorial.

AIDS is no longer the leading cause of death for all Americans ages 25 to 44.

AIDS Memorial Quilt display in Washington covers over 20 acres of the National Mall with 80,000 names of people lost to AIDS.

1997 - Due largely to the use of HAART, AIDS-related deaths in the U.S. decline by 47% compared with the previous year.

Drug resistance emerges as an area of concern within the AIDS community.

1999 - The WHO announces that HIV/AIDS has become the fourth biggest killer worldwide and the number one killer in Africa.

2001 - The first annual observance of HIV Vaccine Awareness Day.

2002 - HIV is the leading cause of death worldwide among ages 15 to 59.

The U.S. announces a framework that will allow poor countries to gain greater access to drugs needed to combat HIV/AIDS.

The FDA approves the first rapid HIV diagnostic test kit for use in the U.S. that provides results with 99.6% accuracy in less than 20 minutes.

2003 - George W. Bush announces the President’s Emergency Plan for AIDS Relief (PEPFAR).

2006 - The first once daily single-pill regimen, Atripla, is approved.

2007 - The CDC reports over 565,000 people have died of AIDS in the U.S. since the first cases were reported in 1981.

2008 - The CDC releases new HIV case estimates demonstrating that the U.S. epidemic is worse than previously thought.

2009 - The FDA approves the 100th antiretroviral drug.

2010 - The U.S. Government officially lifts the HIV travel and immigration ban.

The Obama Administration releases the first National HIV/AIDS Strategy for the United States.

June 5, 2011 - Marks 30 years since the first AIDS cases were reported.